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Newborns & Infants Care details the complex systemic adaptations required for survival, including the initiation of respiration, circulatory changes such as the closure of the ductus arteriosus and foramen ovale, and thermoregulatory mechanisms like nonshivering thermogenesis and brown fat metabolism used to prevent cold stress. The text emphasizes systematic assessment strategies, utilizing tools such as Apgar scoring to evaluate immediate adaptation and the Ballard Maturational Assessment to determine gestational age, alongside comprehensive physical examinations that distinguish between normal variations—such as acrocyanosis, vernix caseosa, and Mongolian spots—and pathological abnormalities. Significant attention is dedicated to health promotion and safety, outlining standard prophylactic interventions like vitamin K administration and erythromycin eye ointment, newborn metabolic screenings for conditions like phenylketonuria and hypothyroidism, and critical safety education regarding sudden infant death syndrome (SIDS) and proper car seat installation. Nutritional management is explored in depth, highlighting the immunological and developmental benefits of breastfeeding compared to formula feeding, as well as the timeline for introducing solid foods. Furthermore, the chapter integrates foundational developmental theories, specifically Erikson’s psychosocial stage of trust versus mistrust and Piaget’s sensorimotor cognitive stage, to frame the expected growth milestones during the first year, while also addressing the management of common complications such as hyperbilirubinemia, hypoglycemia, and congenital anomalies like cleft lip and palate.