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Essential physiological concepts explored include neuron and glial cell functions, action potential propagation, synaptic transmission through neurotransmitters, reflex arc mechanisms, and cerebrovascular circulation patterns. The chapter emphasizes systematic assessment methodologies, progressing from comprehensive health history collection to detailed physical examination techniques that evaluate mental status, cranial nerve function, sensory and motor responses, coordination abilities, and deep tendon reflexes. Standardized assessment tools are thoroughly discussed, including the Mini-Mental State Examination, Montreal Cognitive Assessment, and Confusion Assessment Method for detecting cognitive impairment and delirium. Diagnostic procedures covered encompass lumbar puncture techniques, electroencephalography interpretation, computed tomography applications, and magnetic resonance imaging utilization in neurological diagnosis. Special consideration is given to age-related neurological changes in older adults, including decreased nerve conduction velocity, diminished reflex responses, and normal cognitive variations that must be differentiated from pathological conditions. The chapter concludes with nursing responsibilities in recognizing early signs of neurological disorders such as cerebrovascular accidents, neurodegenerative diseases, movement disorders, and demyelinating conditions, emphasizing patient safety, therapeutic communication, and health promotion strategies.