Insulin Resistance
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Top explanations for Insulin Resistance
Obesity, Starvation, and Anorexia of Aging — Pathophysiology: The Biologic Basis for Disease in Adults and Children▶ 8:30They produce far fewer inflammatory cytokinesAnd this specific type of fat expansion has a much lower association with the development of insulin resistanceYeah, there's a hormonal driver behind this, rightEndocrine Pancreas & Glucose Regulation — Medical Physiology: Principles for Clinical Medicine▶ 20:08Specific enzymes called protein pyrocine phosphatases, or PTPs, strip those activating phosphate groups offAnd this termination mechanism is where insulin resistance often starts, isn't itIt isIntegration of Metabolism Explained — Biochemistry▶ 13:36And then there are two that do the opposite, RBP4 and resistantThey actually promote insulin resistanceWhich sounds counterintuitive, but the thinking is that they might be another necessary brake on the system